This paper suggests a novel and important aspect of the neurodegenerative process that needs to be better understood. We do know from studies at Durham University in the UK that 1065-1075nm light stimulation will enhance health and protect neurons from damage and thereby reduce the amount of fragments being created that may increase neural inflammation. Further research is needed to determine if the immune system is also enhanced in being able to remove these fragments more efficiently. Read about the study here:
Clinical trials at Quietmind Foundation using the 1065-1075nm pulsed infrared helmet are ongoing and people with diagnoses of early to mid-stage dementia are encouraged to contact Dr. Berman 610-940-0488 to discuss eligibility for the new home-based 60-day light therapy program.
We see the new technologies are all set to revolutionize medical care and personal growth. I"m very excited to see the range of noninvasive technologies being described especially transcranial ultrasound. Quietmind is going to explore this option in future research projects at its clinic in Elkins Park.
We need to be more conscious of the risks of even a single head trauma given the findings here about the connection to developing memory disorders including Alzheimer's disease. This is why children playing sports should be evaluated regularly for signs of dysregulated brain activity and steps taken to correct these patterns including home-based neurofeedback training and photobiomodulation.
Protein tangles linked with dementia seen in patients after single head injuryhttps://www.sciencedaily.com/releases/2019/09/190905103013.htm
Abstract: The primary goal of the present research is to study the effect of a neurofeedback training (NFT) period on balance problems associated with Parkinson’s disease. Sixteen patients were selected through purposive sampling and were randomly divided into experimental and control groups. The research procedure included eight sessions. Prior to and after training, pre-tests and post-tests of static and dynamic balance were administered using ‘‘limit of stability’’ for the Biodex as well as the Berg scale. The results revealed that, after neurofeedback training, a statistically significant improvement in both static and dynamic balance in the experimental group was achieved. The means of the Biodex and Berg scores in the experimental group increased from 18.87 to 42.87 and 17.62 to 46.37, respectively. The means of the Biodex and Berg scores in the control group in the pretest were 18.25 and 17.75 and increased to 20.00 and 20.50, respectively. The results suggest that NFT can improve static and dynamic balance in PD patients.
The application of infrared light stimulation to treat the underlying disease processes in dementia are readily explained in this excellent review paper by Michael Hamblin. I think there is now ample support for seeing this as an effective noninvasive, non-drug treatment especially when combined with brainwave biofeedback and functional medicine as described by Dale Bredesen and those following his model of treatment. Quietmind Fdn. has long promoted this tripartite treatment approach in our clinic and in our consultation with other providers and clinics around the world.
New blood markers that reflect risk for Alzheimer’s disease (AD) are uncovering important modifiable risk factors to be aware of to dramatically reduce the likelihood of ever suffering from this cruel disease. The latest study shows that just one night of sleep disruption is associated with an increase in these blood markers.
The primary brain lesions of AD are the result of deposits of a substance known as beta-amyloid. Although the immune cells in the brain normally remove beta-amyloid and plaque, research is beginning to characterize a chronic and excessive inflammatory reaction to amyloid proteins in the brain in susceptible individuals that can promote AD. Blood measurements of a protein called tau that is formed from toxic beta-amyloid as well as a protein that acts as the internal skeleton of brain cells known neurofilament light chain (NfL) protein can predict neurodegeneration years before clinical symptoms appear in AD. When brain cells are damaged, tau and NfL are released into cerebrospinal fluid and then the blood.
Poor sleep quality is associated with a significant risk for Alzheimer’s disease. For example, researchers from the Washington University School of Medicine in St. Louis found that the inability to sleep through the night was associated with an increased risk the preclinical form of Alzheimer’s disease. Subjects who were the least efficient sleepers in the study were five times more likely to have preclinical form of Alzheimer's. While researchers are exploring the formation of the beta-amyloid as being the cause of the poor sleep quality, a more likely explanation is that the poor sleep quality is actually the cause of the beta-amyloid formation.
During the deeper levels of sleep the repair mechanisms and antioxidant system of brain cells are heightened. Sleeping pills seem to exacerbate this situation. Use of sedative hypnotic drugs (sleeping pills) was associated with a whopping 230% increase risk of AD over an eight-year period in a study in France while in a study in the U.K., the risk was even greater over a 22-year follow up study– a dramatic 294% increase. The link between sleeping pill usage and the dramatic increased risk for AD may be the result of the fact that these drugs typically negatively impact the ability to achieve deeper levels of sleep.
"Mental disorders often involve difficulty with complex cognitive functions, such as decision making, emotional self-regulation, or behavioral adaptation to changing circumstances. Those functions arise from the carefully timed and orchestrated synchrony of activity across multiple structures1—in other words, from network activity. It should therefore be possible to treat mental disorders by identifying abnormalities in that network activity and restoring them to healthy patterns. "
Targeting Cognition and Networks Through Neural Oscillations:Next-Generation Clinical Brain Stimulation
Alik S. Widge, MD, PhD; Earl K. Miller, PhD
Published Online: May 22, 2019. doi:10.1001/jamapsychiatry.2019.0740
A study published in the American Academy of Neurology demonstrated the neurophysiological and biochemical value of repeated compression using blood pressure cuffs on ones arm and leg for 5 minutes. Brain blood flow was improved for over 24 hours beginning 6 hours after the compression treatments were conducted.
This struck me as a relative benign and cost effective method of treatment for people with neurodegenerative and neurodevelopmental conditions, e.g, dementia and autism. I recalled the gowing evidence for intermittent hypoxia and hypocaloric interventions enhancing mental and physical and immune system functioniong. I've been made aware of its use in physical fitness training and want to explore how it could be developed into a safe, low-cost, noninvasive and rather useful 'outside in' treatment for older adults where blood flow is constrained by various forms of cardiovascular disease and impaired functioning.
Then I recalled Stan Grof's early work on what he termed basic perinatal matrices (Grof, 1976) where the fetus is compressed during the birth process and this confers important psychophysiological information that substnatively influences their future development. I saw a connection to Grof's insight about the challenges we experience in the birth process can carry forward into later life and manifesting as emotional and behavioral difficulties. Here we can see how the contraining of blood flow and then its sudden release repeats the experience of compression in the birth canal and subsequent release into progressively more independent, self-organizing and self-sustaining life. I then associated the paper's description of remote ischemic preconditioning to my use of Bioenergetic therapy as a psychophysiological way to enhance body-mind flexibility and self awareness.
Quietmind's current treatment model focuses on using photobiomodulation to increase cortical microcapillary perfusion, regional cerebral blood flow, ATP and specific chaperone proteins while reducing beta amyloid buildup. This is combined with brainwave biofeedback training to repair the dysregulated neural connectivity and functional medicine that can address any underlying infectious or metabolic sources of impaired immune response and systems-oriented Bioenergetic Analysis to re-establish and support more grounded emotional and interpersonal functioning.
Noninvasive non-drug treatment of dementia and other neurodegenerative disorders with photobiomodulation is getting more evidence of its effectiveness published in the traditional scientific literature. We are gratified and excited to see this approach gaining traction and hope this can lead to increased interest in Quietmind's integrated treatment model of photobiomodulation with infrared light and brainwave biofeedback training. This study builds on the work done at MIT with animals and shows how the pulsed light can influence neurochemistry and cellular communication processes to mitigate neurodegenerative activity.
I found a paper https://www.ncbi.nlm.nih.gov/pubmed/21459521
Med Hypotheses. 2011 Jun;76(6):769-73. doi: 10.1016/j.mehy.2011.01.020. Epub 2011 Apr 2.Tardive dysphoria: the role of long term antidepressant use in-inducing chronic depression.El-Mallakh RS1, Gao Y, Jeannie Roberts R.
This provoked me to inquire of my colleagues as to why there'd been no further exploration of this issue to be found in teh literature since 2011 and I got this reply from Robert Thatcher a neuroscientist and developer of the Neuroguide EEG analysis software that we use at Quietmind for our clnical and research activities. It is clear that the continued use of SSRI medications is now getting more critical attention now 30 years after the arrival of Prozac. Neurofeedback and other treatment methods are able to provide similar results without side effects and that last long after the training process has been completed. Here's Dr. Thatcher's reply:
This post concerns he science and publications showing negative effects after long term use of antidepressants. The negative effect of the antidepresssants is called Tardive Dysphoria which is chronic depression induced by long term use of antidepressants. There are several interesting studies on this topic if one does a simple Google search as well as a search of the National Library of Medicine database, e.g., https://www.ncbi.nlm.nih.gov/pubmed/30199999Tardive dysphoria: the role of long term antidepressant use in-inducing chronic depression
A common hypothesis is that anti-depressants inhibit re-uptake that results in increased serotonin in the extracellular space however over time there are compensatory mechanisms that remove serotonin faster than the drug can block re-uptake or different re-uptake mechanisms develop that result in a worse and chronic outcome.
Ketamine has a different mode of action, e.g., midline thalamus de-coupling to the medial frontal lobes and hippocampus that appears to disrupt a cyclic dynamic and sort of refreshes the circuity for a while,e.g., Cortical-brainstem (nu. Raphe) regulatory control mechanisms. A search of the National Library of Medicine database using the search terms "Depression Brain Network" results in 2,875 citations. There is good agreement about the hubs of this network between different imaging modalities such as fMRI, PET and EEG/MEG. Therefore, a reasonable idea is to measure the brain networks related to depression using QEEG and LORETA as a baseline assessment and then use NFB to reinforce increased stability and efficiency of the nodes and connections between the hubs of the depression network as well as to use QEEG to assess the relative effectiveness of non-SSRI treatment.. As Wes stated, exercise and good diet (Typtophan is a precursor of serotonin) and lifestyle changes and perhaps also Ketamine. However, given the risk of doing harm based on the over use of anti-depressant drugs as published in the scientific literature points toward considering alternative treatments.
Bob Thatcher, PhD Applied Neuroscience Inc.
Our team regularly publishes articles and blog posts on the latest research and news coming out of our group and the field in general.