Hard to imagine how anyone who understands what it must've been like to be working at Ground Zero on and after 9/11 could think there weren't going to be physical and mental consequences for the workers and survivors of that tragedy. No one should forget the chaos that followed in terms of people struggling to find survivors and the horror that they all endured in the process. It should not then surprise anyone that 20 years later we are witnessing the mental and emotional devastation that typically appears when people are in their 70s and 80s now is clearly evident in these folks in their 50s. The level of toxicity they were exposed to in a matter of days or weeks, most people never come close to in a lifetime.

Our work with people strugging with memory loss has taught us to look to the lifestyle and levels of exposure to black  mold and other neurotoxins as well as being infected with spirochetes from tick bites. We also looked to the trauma that they endured in their lives from sexual and physical abuse, chronic pain and respiratory challenges as well as addiction to substances or disordered eating. The mismanagement of emotional stress challenges our immune system along with every other functional system in our body. How would that not add to the degrading our capacity to maintain a healthy internal biological and psychological ecosystem? 

The report now about first responders developing early onset dementia comes as no surprise to me or anyone in my professional circle and it offers cold comfort to see these things coming and know there's very little attention being given let alone resources put toward mitigation of the downside risk and the inevitable disaster facing these brave souls who put their lives on the line for us every day.  Grief over the enormity of the loss we suffered and that which was yet to come turned to anger shortly after the towers fell and it was clear that precious little attention being paid to the long term impact of being on the pile. The shocking enormity of the moment constrained most of our thinking to short term problem solving, coping with the next moment and the next. The axiom of those in recovery from addiction became the mantra for the country... 'one day at a time.'

There are tools available to these people to help them deal with their symptoms and possibly reverse their conditions or at least change the slope of decline. We've shown this to be true in our research on the use of self-administered transcranial infrared photobiomodulation (light therapy) and brainwave biofeedback. We are ready to help these heros first by letting them know that there is hope for recovery and the truth that time is the enemy in this situation. The sooner you start treatment the greater the chances are for improvement. Put the resources behind noninvasive technologies that have been proven effective in gold standard clinical trirals, that have no side effects, are easily deployed and would cost a fraction of what has been spent on the 500+ failed pharmaceutical trials in the vain search for a single molecule solution to a systemic disease. Researchers like Tom Lewis PhD (healthrevivalpartners.com) and Dale Bredesen (apollohealthco.com) foundational work has shown us there are alternatives to treating dementia, let's put them to work now for these brave souls who deserve nothing less than our absolute best. 
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https://www.washingtonpost.com/magazine/2021/08/30/911-first-responders-dementia/?itid=pr_hybrid_experimentrandom_with_top_mostshared_3_na-ans_3

I think Prof. Hamblin's opinions on photobiomodulation are as sound as anyone's given his depth of knowledge and experience in this field. I've had the pleasure to collaborate with him several book chapters and articles over the years and have never come away from an interaction not having learned something new and valuable about how to think about the mechanisms and clinical application of LED light. 

I'm extracting some comments that I think are of particular importance in gaining a level of appreciation for what is possible in the application of this technology to both the acute and systemic health problems we now face, especially in the era of the COVID 19 pandemic. These comments are taken from an interview Prof. Hamblin did with Joseph Mercola, MD

The range of near infrared goes from 700-1200nm 
 "You can't say that light is a food. What light does is it allows you to use your food much more efficiently."

 "By and large, the thing to remember about photobiomodulation is it's highly biphasic in dose. Many people have got themselves into trouble by giving too much light."
power density is 10mw 1J every 100 sec. 10J is a reasonable dose. 
2mw-40mw is the likely effective range and the ideal 

lasers have focused spots. 10mw laser delivers 10mw not 1W. 

One trend is to have flexible LEDs that are wearable for pain treatment. OLEDs are in fact flexible and mostly in the red range. 

Ideally, we want to have highly active wavelengths of light that penetrate well into the body."

nanostructured water is present on hydrophobic surfaces and inside the cell of all membranes. The mitochondria are full of nano-structured water. These can strongly influence ion channels with no change in temperature. 

The kind of light that produces the other nitric oxide pathways are blue and green mostly. 
Light isn't a food, it does help the cells make the best use of food. Combined with light exercise the adding of infrared light is a great positive benefit. 

 All the 800s seem to be the same and the 660s are mostly the same. So 660 can confer the same benefits as the 800s. 

Light is very good at generating stem cells in bone marrow. 

In my opinion the effects are so surprisingly good that in 5-10 years PBM for AD has to be pretty much out there. 

Changes macrophage phenotype from M1 to M2 are really good at improving microglial function and phagocytosis (gobbling up the garbage, e.g., amyloid plaques, tau tangles, alpha synuclein aggregates.

 I can see a day when every household will have one or two light therapy devices.

Pulsed frequency is showing to be better than continuous wave stimulation.

The latest review of Aducanumab (Aduhelm), the recently FDA approved medication for Alzheimer's, has been determined to have ​'Zero Benefit' as determined by the California Technology Assessment Forum in a recent report to the  Institute for Clinical and Economic Review (ICER). The stunningly depressing and ironic fact is that the report decries the lack of effective medications for Alzheimer's while not considering supporting treatment alternatives, e.g., transcranial infrared photobiomodulation, that have published clinical efficacy in reversing both cognitive and behavioral symptoms in subjects diagnosed with mild to moderate dementia. 

Hopefully more people will recognize that there are options available to influence the slope of decline as well as taking steps to prevent disease onset using what are considered 'alternative' approaches like those advocated by Dale Bredesen and Apollo Health (https://www.apollohealthco.com/). Quietmind Foundation is proud to have been invited to partner with Apollo Health in advocating for the development of noninvasive, non-drug treatment protocols for Alzheimer's and other neurodegenerative disorders. 

Link to the Medscape article: zero benefit to dementia patients while costing $56,000/yr.

The new drug from Biogen carries a very hefty price tag along with a very limited level of efficacy that has now been further limited by recent FDA labeling guidelines. The drug that costs $56,000 a year and is delivered intravenously is designed to flatten the slope of cognitive decline and will not reverse memory loss, behavioral challenges or other functional deficits.

The irony is not lost on us that transcranial infrared photobiomodulation, a treatment for which there is published evidence of reversal of memory, mood and motor symptoms and costing less than $4000, has not been afforded much recognition within the mainstream Alzheimer's treatment community. We are hopeful this will changes as clinicians like Dr. Dale Bredesen recognize and advocate for the use of this technology in the treatment of neurodegenerative disorders.

Quietmind Foundation has been selected to partner with Dr. Bredesen's company Apollo Health to provide consultation and training in the clinical use of photobiomodulation with their practitioners and patients. We are excited by this important opportunity and look forward to working with this community of providers and consumers and hope the word will spread and more people will be able to take advantage of this important neurophysiological health resource.


​www.medscape.com/viewarticle/954403?src=WNL_mdpls_210709_mscpedit_psych&uac=60587DN&spon=12&impID=3495260&faf=1

https://images.unsplash.com/photo-1572625259782-94ac200efcdb

Alzheimer’s was first identified in 1906. Over a hundred years later, there's still no curative treatment for the disease. What we do have are potential procedures, lifestyle changes, and medications that help slow down its progression. Just recently, the Food and Drug Administration (FDA) approved a new Alzheimer’s drug, Aduhelm. And it’s been met with a lot of mixed reactions from the scientific community. To get FDA approval, drugs must go through two Phase III trials with positive results. Aduhelm skipped both and only presented preliminary results. It’s one of the first few drugs specifically made for Alzheimer’s; bypassing the processes may set a negative precedent for further research and trials. It creates more doubt and disagreements within the scientific community and mistrust among the general public.

There’s no space for dubious processes in Alzheimer’s treatment research, not when there are a number of other roadblocks to overcome.
Lack of Funding
A study conducted by the Rush Alzheimer’s Disease Center found that Alzheimer’s-related deaths are now nearly on par with cancer deaths, claiming 500,000 lives annually. Despite that, research funding for Alzheimer’s ($550 million) doesn’t even come close to half of the funds dedicated to cancer research ($5.7 billion). In fact, many research teams have had to turn to private funding and seek out donations to continue their studies on non-drug Alzheimer’s treatment. This isn’t to minimize the severity of cancer – it still is a serious and debilitating disease – but considering how Alzheimer’s is just as pervasive, it should also be prioritized.

From a macro perspective, the U.S. ranks low in elderly care among other rich countries. Perhaps since Alzheimer’s is perceived more as a condition of the elderly, it’s not given much importance. The study highlighted how dire the need is for government and systemic support. In response to the worrying figures, Alzheimer’s advocates have called for a sense of urgency from the government. They pointed out that without swift action and effective treatment, Alzheimer’s-related deaths will continue to rise. It’s a condition that’s just as life threatening as cancer and there should be more support in finding cures.



Conflicting Theories
A compounding effect of the lack of funding is the lack of knowledge about Alzheimer’s disease. While there’s a general understanding that Alzheimer’s is linked to the plaque formation of beta-amyloid in the brain, researchers are still debating whether it’s a cause or a symptom of the disease – this is a concern since these plaques are used as biomarkers of Alzheimer's.

What’s more, there’s a disproportionate standard of imaging and non-imaging biomarkers. Doctors generally rely on lab tests, scans, and exams to evaluate the symptoms of the disease. But there’s a need to advance non-imaging biomarkers since the condition is difficult to confirm based on imaging diagnostics alone. There are behavioral and cognitive biomarkers that need to be studied and determined. It's only when these theories are substantiated that effective treatment can be made.
Centralized Research
Studies on Alzheimer’s have been dominantly focused within the neuroscientific field. This means that only a select few are regarded as authorities on the subject. However, that’s been challenged in the modern interdisciplinary research environment. Professionals from different disciplines need to have access and opportunity to spur on Alzheimer’s research.

Today, many healthcare and research professionals are pursuing continuing education and exploring specialties in cognitive sciences, particularly through online institutions that allow them to study and maintain their careers. This is evident in online MSN degrees, in particular, which lead nurses to more advanced practice specializations. These degree-holders are taught to take a holistic approach, providing both medical care and assistance in making lifestyle choices as well. This makes them valuable assets to Alzheimer’s research, especially as we begin to see the condition beyond just the medical lens. Moreover, research for Alzheimer’s treatment should run the gamut from a range of biomedical science perspectives – or even those with training in engineering and computational science – to speed the process along. Expertise in neuroscience alone can only take treatment discovery so far.
Treatment Options Focused on Pharmacology
Despite the growing body of published clinical evidence that the symptoms of Alzheimer’s and other dementias can be treated and in some cases prevented – by lifestyle change, photobiomodulation, neurofeedback training and functional medicine, many healthcare professionals still insist on single molecule pharmacology. This is due, in part, to the skewed credence given to traditional allopathic neurologists who staunchly advocate for medications and invasive therapies. Much like all new views in medicine, new ideas are often initially met with resistance and overcoming resistance takes time to educate physicians and relentless patient advocacy that allow people to make new choices for their loved ones and themselves.

As it is, medical institutions can barely service the demand. Home-based, self-administered, systemically-oriented treatment solutions that are safe, affordable and grounded in rigorous scientific evidence are what is needed. One such solution is the RECODE protocol advanced by Dr. Dale Bredesen. It’s essentially a lifestyle modification method that aims to delay or protect against neurodegeneration. The protocol suggests targeting and improving 36 lifestyle factors that have been shown to contribute to cognitive decline. The protocol advocates for removal of systemic toxins include heavy metals, mold and other environmental pathogens, regular aerobic exercise, and intermittent fasting and a Mediterranean diet. Dr. Bredesen and his colleagues at Apollo Health strongly support the idea that dementia is the result of long term systemic inflammation and that changes of the kind he suggests can enhance cognitive function and reverse decline at any age. Recent dialogue between Quietmind Foundation President Marvin Berman and Dr. Bredesen (Bredesen Facebook Live have shown how closely their ideas and practices are aligned and future combined trials have been mentioned.

Given the support and chance to grow, many non-invasive and non-pharmacological methods could be discovered to treat Alzheimer’s. These could be game-changing for both patients and the healthcare system. These types of treatments would allow Alzheimer’s patients to require less inpatient care, letting them continue treatment at home.

Even if there are a number of roadblocks, there’s still much hope for a safe, effective and affordable Alzheimer’s treatment. Recognizing these challenges is the first step in overcoming these hurdles.
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This article was prepared especially for www.quietmindfdn.org by Alice Palmer

I was extremely pleased to be interviewed by Dr. Dale Bredesen and Julie Gregory on Dr. Bredesen's Facebook Live channel on Thursday.
We covered a range of topics related to the mechanisms of action of infrared light photobiomodulation (PBM) and other forms of non-invasive stimulation, neurofeedback training and how these safe, reliable, affordable technologies can enhance the effectiveness of functional medicine as a treatment model for neurodegenerative conditions. This will hopefully be viewed those patients and clinicians who have trained and are affiliated with Apollo Health in order to expand the availability of these types of home-based, low-cost, non-drug, noninvasive treatment options for people seeking to stop or prevent cognitive and functional decline. 

We will post the full transcript of the program along with additional links to information discussed in the program and some discount codes for purchasing the light therapy devices. I'm quite keen to see how we can put together a trial that will combine RECODE, PBM and neurofeedback.    

Researchers are now able to report that the COVID 19 virus has the ability to cause small vessel damage to the brain tissue itself and not impair neuronal activity as was previously thought. The key point was made by the study author, Anna Cervantes, MD "Even though most of the coagulopathy is largely venous and probably microvascular, this does affect the brain through a myriad of ways".  Our efforts to encourage the use of photobiomodulation are rooted in the knowledge that inflammatory processes include microvasular occlusion resulting in hypoperfusion. These are the fundamental hallmarks for all neurodegenerative disorders and why we advocate so strongly for taking prophylactic steps now to protect our brain with near infrared stimulation and functional medicine to reduce or hopefully remove neurotoxicity. 

The combined approach of photobiomodulation and neurofeedback has proven to be of considerable benefit to many patients who needed to feel a sense of hope and control over their condition which is a key part of the integrative health model at QMF. 

www.medscape.com/viewarticle/944467?src=soc_lk_share