Study PI, Indu Subramanian, MD, clinical professor, Department of Neurology, UCLA David Geffen School of Medicine, Los Angeles Indu Subramanian, MD, clinical professor, Department of Neurology, UCLA David Geffen School of Medicine, Los Angeles found adverse childhood experiences (ACEs) are associated with increased motor and nonmotor symptoms of Parkinson's disease (PD) and reduced quality of life (QOL).
Sadly and not surprisingly, this was the first study evaluating childhood trauma and PD. Subjects with PD who reported more than one ACE all experienced a statistically significant decrease in QOL, and for each additional ACE, there was significant worsening of motor symptoms.
I'm pleased that our research on the use of transcranial 1070nm photobiomodulation (tPBM) rapidly produced a decrease in both motor and behavioral symptoms in PD subjects. The data was obtained during post study narrative reviews with clinical trial subjects who were enrolled in a expanded feasibility trial focusing on tPBM impact on cognition. A subgroup of subjects were dually diagnosed with PD and early to mid-stage dementia and these subjects and their caregivers reported significant improvement in both cognitive, motor, expressiveness, sleep quality and decreased apathy.
The study was published online February 20 in Neurology: Clinical Practice .
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