I think Prof. Hamblin's opinions on photobiomodulation are as sound as anyone's given his depth of knowledge and experience in this field. I've had the pleasure to collaborate with him several book chapters and articles over the years and have never come away from an interaction not having learned something new and valuable about how to think about the mechanisms and clinical application of LED light.
I'm extracting some comments that I think are of particular importance in gaining a level of appreciation for what is possible in the application of this technology to both the acute and systemic health problems we now face, especially in the era of the COVID 19 pandemic. These comments are taken from an interview Prof. Hamblin did with Joseph Mercola, MD
The range of near infrared goes from 700-1200nm
"You can't say that light is a food. What light does is it allows you to use your food much more efficiently."
"By and large, the thing to remember about photobiomodulation is it's highly biphasic in dose. Many people have got themselves into trouble by giving too much light."
power density is 10mw 1J every 100 sec. 10J is a reasonable dose.
2mw-40mw is the likely effective range and the ideal
lasers have focused spots. 10mw laser delivers 10mw not 1W.
One trend is to have flexible LEDs that are wearable for pain treatment. OLEDs are in fact flexible and mostly in the red range.
Ideally, we want to have highly active wavelengths of light that penetrate well into the body."
nanostructured water is present on hydrophobic surfaces and inside the cell of all membranes. The mitochondria are full of nano-structured water. These can strongly influence ion channels with no change in temperature.
The kind of light that produces the other nitric oxide pathways are blue and green mostly.
Light isn't a food, it does help the cells make the best use of food. Combined with light exercise the adding of infrared light is a great positive benefit.
All the 800s seem to be the same and the 660s are mostly the same. So 660 can confer the same benefits as the 800s.
Light is very good at generating stem cells in bone marrow.
In my opinion the effects are so surprisingly good that in 5-10 years PBM for AD has to be pretty much out there.
Changes macrophage phenotype from M1 to M2 are really good at improving microglial function and phagocytosis (gobbling up the garbage, e.g., amyloid plaques, tau tangles, alpha synuclein aggregates.
I can see a day when every household will have one or two light therapy devices.
Pulsed frequency is showing to be better than continuous wave stimulation.
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