Proteins Involved in Alzheimer's Can 'Overcook' Cells Through Heat
This recent paper from researchers at Cambridge U showed that amyloid buildup in cells increases intracellular temperature that damages cell viability. The idea that a buildup of any kind around something increasing ambient temperature is very reasonable and points to cortical perfusion as a therapeutic target,i.e., increase the system's temperature regulatory capacity.
Spilt, (2008) showed In patients with dementia, cerebral blood flow was 108 mL/min lower than that in subjects of the same age with optimal cognitive function (551 vs 443 mL/min, P < .001). Moore and others at showed the changes in cortical functioning in relation to changes in blood flow. It was also made clear that the function of increased perfusion during neuronal firing was to support temperature regulation, i.e., drawing heat aware to prevent damage.(www.scientificamerican.com/article/blood-flow-may-be-key-player/)
Our efforts at QMF with photobiomodulation (PBM) show that increasing cortical perfusion and vascular flexibility using LED-based transcranial 1070nm photobiomodulation can signiticantly improve motor, cognition and behavioral symptoms of people diagnosed with probable Alzheimer's, FTD, Parkinson's disease and Lewy Body Dementia. I see this as good reason to question the amyloid hypothesis' centrality, i.e., suggesting it is the cause of Alzheimer's and other dementias, given that, 1) the percentage of amyloid plaques within the brains of non-demented age-adjusted individuals had the same percentage of amyloid plaques found within the brains of AD patients , and 2) no relationship was found between the number of amyloid plaques located in the brains of AD patients and their degree of dementia severity [2 (J Alzheimers Dis. 2022; 85(4): 1419–1422.
Clearly amyloid aggregation will increase temperature like a blanket keeps the body warm, however, our primary therapeutic task is to both flush amyloid out of the system by improving glymphatic drainage and improving cortical perfusion thereby reducing overall inflammation and better oxygenate damaged tissue.
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